青云瑞晶生物科技有限公司 | Academic achievements

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Technical Articles
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Academic Achievements
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The ITQ-37 Mesoporous Chiral Zeolite
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Nature, volume 458, pages 1154–1157 (2009)

The synthesis of crystalline molecular sieves with pore dimensions that fill the gap between microporous and mesoporous materials is a matter of fundamental and industrial interest(1-3). The preparation of zeolitic materials with extralarge pores and chiral frameworks would permit many new applications. Two important steps in this direction include the synthesis(4) of ITQ-33, a stable zeolite with 18 x 10 x 10 ring windows, and the synthesis(5) of SU-32......

A Zeolite Family with Expanding Structural Complexity and Embedded Isoreticular Structures
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Nature, volume 524, pages 74–78 (2015)

The prediction and synthesis of new crystal structures enable the targeted preparation of materials with desired properties. Among porous solids, this has been achieved for metal–organic frameworks1,2,3, but not for the more widely applicable zeolites4,5, where new materials are usually discovered using exploratory synthesis. Although millions of hypothetical zeolite structures have been proposed6,7, not enough is known about their synthesis mechanism......

FAD-dependent Enzyme-catalysed Intermolecular【4+2】Cycloaddition in Natural Product Biosynthesis
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Nature Chemistry, volume 12, pages 620–628 (2020)

The Diels–Alder reaction is one of the most powerful and widely used methods in synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the importance of Diels–Alder reactions in the biosynthesis of numerous secondary metabolites, no naturally occurring stand-alone Diels–Alderase has been demonstrated to catalyse intermolecular Diels–Alder transformations. Here we report a flavin adenine dinucleotide-dependent enzyme......

Mixed Lineage Kinase Domain like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
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Cell, volume 148, issues 1–2, pages 213-227

The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiological and pathological conditions, including development, tissue damage response, and antiviral immunity. Here, we report the identification of a small molecule called (E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide......