Service

Business Scope

Solving tough problems in solid-state drug research based on the underlying technology MicroED

Crystal form research

We can provide crystallographic screening studies, stability studies and bioactivity evaluation at an early stage of drug development. It can help researchers select superior crystalline forms by providing the scientific basis and can ensure the drug quality.
Multiple ways to screen for crystal form
Salt/eutectic culture and screening
Confirmation of drug molecular structure (MicroED, single crystal culture)
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Solid state testing

Solid-state testing of crystal forms enables the efficacy and safety of drugs to be assessed. Determination of the content of active crystal forms in APIs or formulations enables precise control of drug quality.
Identification of crystal form
Quantitative analysis of crystal form (single peak method, Rietveld method)
X-ray powder diffraction (XRPD)
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Crystallization process development

The crystallization process is very important in the drug development process which gives the API a specific purity, crystal form, crystal habit, particle size distribution and dissolution rate.
Selection of the most suitable crystallization method
Regulation of crystal nucleation and growth
Ensuring a qualified end product
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Main characterization techniques

2

MicroED Advantages

  01    No or much less difficult crystallization
Nanocrystals/powder crystals/needle crystals.
MicroED technology can resolve crystals as small as 100nm
  02    Significant reduction in non-required project cycle time
No need for time-consuming large single crystal cultivation process
Significantly increases the success rate and shortens the project development cycle 
  03    No significant drop in required crystalline material
X-ray single crystal diffraction techniques generally require crystalline material above the gram level.
MicroED generally requires only a few tens of mg
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Conventional single crystal X-ray diffraction requires crystal size >50 microns
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MicroED requires only >0.1 micron